ABSTRACT
Objective: to investigate the relationship between procalcitonin in the differential diagnosis of bacterial coinfection in COVID-19 patients. Method: a cross-sectional retrospective study conducted between February and March 2021 in the Intensive Care Unit of a public hospital from southern Brazil by filling in a form. Descriptive statistical analyses were performed, as well as of association between variables. Results: of the 231 patients, 28.14% presented infection (63.20% in the lungs), 25% had bacteria isolated, 77.49% used antimicrobials and, in 14.72% of the cases, procalcitonin > 2 ng/mL. There was a significant association between antimicrobial use and infection (p=0.001), isolation of bacteria (p<0.001), topography of the infection (p<0.001) and procalcitonin values (p<0.001). Procalcitonin use showed an association with bacterial infection (p<0.001), isolation of bacteria (p<0.001), antimicrobial use (p=0.001) and death (p<0.001). Conclusion: procalcitonin can reduce empirical antimicrobial use and stimulate detection and identification of pathogens, taking into account the clinical and epidemiological data. © 2023, Universidade Federal do Parana. All rights reserved.
ABSTRACT
In the field of air analysis, highlights within this review period included: a new in situ method for measuring resuspended road dust arising from vehicular movements;new ink-printed filter reference materials for black- and elemental-carbon measurements;coupling of a scanning mobility particle sizer to a single-particle-ICP-MS instrument for improved nanoparticle characterisation;developments in total-reflection XRF spectrometry for trace analysis and evaluation of vibrational spectroscopic techniques for measuring respirable crystalline silica in the workplace. The increasing availability of ICP-MS/MS instruments is revolutionising the analysis of environmental samples such as waters for trace elements. The advent of the mass shift mode makes some elements such as P and S much easier to quantify and allows the REEs and some radioisotopes to be determined at much lower concentrations than previously possible. Advances in vapour generation methods are mostly limited to photochemical and chemical vapour generation as reflected in the new table listing the main advances. Solid or liquid phase extraction prior to analysis remains of great interest, although a notable trend is the synthesis of new materials rather than optimisation of commercially available chelating agents and columns. The analytical effort presented in a paper is sometimes much less than the effort put into the synthesis of the materials so one wonders about the likelihood of methods actually being used and results replicated. Notable in the analysis of soils and plants was the unusually large number of review articles - possibly because practical research was hampered by the Covid-19 epidemic. Areas of continued growth were research on nanoparticles, the application of high-resolution continuum source AAS for multielement analysis, the development of miniaturised AES instruments that may ultimately be field-portable and application of LIBS to the analysis of plant materials. A concerted effort to characterise natural minerals that are sufficiently homogeneous to act as reference materials in the microanalysis of geological materials has resulted in the availability of new materials for isotope ratio determinations. Tied to this has been research into U-Pb dating of zircon and a variety of other accessory minerals by LA-ICP-MS and SIMS. New chemometric models have been developed to handle the complex LIBS data arising from the analysis of geological matrices in the field and during ore processing. Studies on the use of ICP-MS/MS to reduce polyatomic interferences in geological applications were widespread, reflecting the availability of such instruments. In contrast, the potential offered by integrating LIBS data with those from LA-ICP-MS has only just started to be explored but is likely to increase with the development of commercial instruments. © 2022 The Royal Society of Chemistry.